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To install BIOKMOD
Extract the file “biokmodXX.zip” with a zip utility (ex:winzip). It will create a folder called Biokmod. Copy this folder in Mathematica directory’AddOns\Applications. It included a folder called documentation where the usage of BIOKMOD is described.
BIOKMOD includes (i) a package to solve system of ordinary linear differential equations (SOLDE) with special application to compartmental and physiological models; (ii) A package for fitting data, it can be applied to fit the transfer rates using experimental data; iii) A specific package for optimal design; iv) Some packages for solving the ICRP Models with applications to internal dosimetry.
Some tutorials are included about: i) Compartmental and physiological modeling (linear and non linear), ii) Random intakes in occupational exposures and their implication in the bioassays, iii) Analytical methods to evaluate the uncertainties associated with the biokinetic model parameters, iv) Non linear regression techniques to the bioassay data fitting, v) Optimal design applied to perform bioassay programs
