To install BIOKMOD
1. Extract the file “biokmodXX.zip” with a zip utility (ex:winzip). It will create a folder called Biokmod. Copy this folder in Mathematica directory’AddOns\Applications
2 Open Mathematica then in the toolbar chose Help-> Documentation Center , you find in the botton “Add-ons and Packages” then click, and you will open a new item called Biokmod where is included the help where the usage of BIOKMOD is described.
This version of BIOKMOD includes (i) a package to solve system of ordinary linear differential equations (SOLDE) with special application to compartmental and physiological models; (ii) A package for fitting data, it can be applied to fit the transfer rates using experimental data; iii) A specific package for optimal design; iv) Some packages for solving the currents ICRP Models, they have special applications to calculate internal dose and bioassay data evaluations.
Some tutorials are included about: i) Compartmental and physiological modeling (linear and non linear), ii) Random intakes in occupational exposures and their implication in the bioassays, iii) Analytical methods to evaluate the uncertainties associated with the biokinetic model parameters, iv) Non linear regression techniques to the bioassay data fitting, v) Optimal design applied to perform bioassay programs
