Our work mainly focuses on the role of glial cells in health and disease. We are interested in gap junctions and connexins, their molecular constituents. More specifically, we’re interested in the role of connexin43 in gliomas, one of the deadliest brain tumors. We have shown that c-Src is involved in the molecular mechanism through which connexin43 reduces cell proliferation and glucose uptake in glioma stem cells (GSCs). Based on this mechanism we have designed a cell-penetrating peptide (TAT-Cx43266-283) that has important antitumor effects in different glioma models (in vitro, ex vitro and in vivo). We are currently investigating how this peptide exerts its effect from a molecular point of view, as well as the effect of this peptide in other cells from the tumor microenvironment (astrocytes and microglia).
Our lab is a consolidated research group recognized by the University of Salamaca (GIR Neurobiochemistry) and the Junta de Castilla y León (UIC013).