Sistema de blogs Diarium
Universidad de Salamanca
Concha Pérez Melero
Unidad de Química Farmacéutica
 
Modelado molecular

Publicaciones

  1. Mario De-Juan-Alberdi, Álvaro G. Temprano, Luis Simón and Concepción Pérez-Melero. Sunlight-driven, catalyst-free synthesis of cyclobutanes by [2+2] cycloaddition of fluorinated heterochalconoids in solution. Eur. J. Org. Chem. 2025, e202500407.
  2. Beatriz Sanchez de Blas, Alvaro G. Temprano, Candela Cives-Losada, Oscar Briz, Elisa Lozano, Maria L. Martinez-Chantar, Matias A. Avila, Mattia Mori, Ahmed Ghallab, Jan G. Hengstler, Concepción Perez-Melero, Francisco A. Bermejo-Gonzalez, Maria J. Monte, Marta R. Romero and Jose J.G. Marin. A novel noninvasive test based on near-infrared fluorescent cholephilic probes for hepatobiliary secretory function assessment. Biomed. Pharmacother. 2025, 187, 118074-118085.
  3. Alvaro G. Temprano, Beatriz Sanchez de Blas, Concepción Pérez-Melero, Ricardo Espinosa-Escudero, Oscar Briz, Paula Cinca-Fernando, Lucia Llera, Maria J. Monte, Francisco A. Bermejo-Gonzalez, Jose J.G. Marin and Marta R. Romero. Synthesis, characterization, and potential usefulness in liver function assessment of novel bile acid derivatives with near-infrared fluorescence (NIRBAD). Bioconjugate Chem. 2024, 35, 971-980.
  4. Elena González-Hernández, Rubén Aparicio, Mercedes Garayoa, M. José Montero, M. Ángeles Sevilla and Concepción Pérez-Melero. Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents. Med. Chem. Commun. 2019, 10, 1589-1598.
  5. Concepción Pérez-Melero. KSP inhibitors as antimitotic agents Current Topics in Medicinal Chemistry 2014, 14, 2286-2311.
  6. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Pelaez and Manuel Medarde. Exploring the effect of 2,3,4-trimethoxyphenyl moiety as a component of indolephenstatins. European Journal of Medicinal Chemistry 2010, 45, 588-597.
  7. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Pelaez and Manuel Medarde. Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation. Bioorganic and Medicinal Chemistry 2008, 16, 8999-9008.
  8. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, José Luis López, Concepción Pérez-Melero, Rafael Pelaez and Manuel Medarde. Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization. Bioorganic and Medicinal Chemistry 2008, 16, 5952-5961.
  9. Carmen Mateo, Raquel Álvarez, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde. Conformationally restricted macrocyclic analogues of combretastatins. Bioorganic and Medicinal Chemistry Letters2007, 17, 6316-6320.
  10. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde. Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins. Bioorganic and Medicinal Chemistry Letters 2007, 17, 3417-3420.
  11. Carmen Mateo, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde. Synthesis of a conformationally restricted polyoxygenated crownophane. Tetrahedron Letters2005, 46 (41), 7055-7057.
  12. Finian Leeper, Dan Hawksley, Stéphane Mann, Concepción Pérez-Melero and Martin D. H. Wood. Studies on thiamine diphosphate-dependent enzymes. Biochemical Society Transactions 2005, 33, 772-775.
  13. Carmen Mateo, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde. Stilbenophane analogues of deoxycombretastatin A-4. Journal of  Organic Chemistry 2005, 70, 6544-6547.
  14. Ana B. S. Maya, Concepción Pérez-Melero, Carmen Mateo, Dulce Alonso, José Luis Fernández, Consuelo Gajate, Faustino Mollinedo, Rafael Peláez, Esther Caballero and Manuel Medarde. Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety. Journal of Medicinal Chemistry2005, 48 (2), 556-568.
  15. Ana B. S. Maya, Concepción Pérez-Melero, Rafael Peláez, Esther Caballero and Manuel Medarde. New naphthylcombretastatins. Modifications on the ethylene bridge. Bioorganic and Medicinal Chemistry 2005, 13 (6), 2097-2107.
  16. Concepción Pérez-Melero, Ana B. S. Maya, Benedicto del Rey, Rafael Peláez, Esther Caballero and Manuel Medarde. A new family of quinoline and quinoxaline analogues of combretastatins. Bioorganic and Medicinal Chemistry Letters 2004, 14, 3771-3774.
  17. Manuel Medarde, Ana B. S. Maya and Concepción Pérez-Melero. Naphthalene combretastatin analogues. Synthesis, cytotoxicity and antitubulin activity. Journal of Enzyme Inhibition and Medicinal Chemistry 2004, 19 (6), 521-540.
  18. Stéphane Mann, Concepción Pérez-Melero and Finian J. Leeper. Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate. Organic and Biomolecular Chemistry 2004, 2, 1732-1741.
  19. Luis G. Sevillano, Concepción P. Melero, Esther Caballero, Fernando Tomé, Lionel G. Lelièvre, Kathi Geering, Gilles Crambert, Rosalía Carrón, Manuel Medarde y Arturo San Feliciano. Inotropic activity of hydroindenic amidinohydrazones. Journal of Medicinal Chemistry 2002, 45, 127-136.
  20. Concepción P. Melero, Manuel Medarde and Arturo San Feliciano. A short review on cardiotonic steroids and their aminoguanidine analogues. Molecules 2000, 5, 51-81.
  21. Luis G. Sevillano, Concepción P. Melero, Melchor Boya, José Luis López, Fernando Tomé, Esther Caballero, Rosalía Carrón, M. José Montero, Manuel Medarde and Arturo San Feliciano. Synthesis and inotropic activity of hydroindene derivatives. Bioorganic and Medicinal Chemistry 1999, 7, 2991-3001.
  22. Concepción P. Melero, Luis G. Sevillano, Esther Caballero, Fernando Tomé, Rosalía Carrón, M. José Montero, Arturo San Feliciano and Manuel Medarde. Hydroindenic guanylhydrazones. Synthesis and evaluation as inotropic agents. Bioorganic and Medicinal Chemistry Letters 1998, 8, 3217-3222.
  23. Manuel Medarde, Esther Caballero, Concepción P. Melero, Fernando Tomé and Arturo San Feliciano. Asymmetric synthesis of (+)-3a-Hydroxy-4,7a-dimethylperhydroindane-1,5-dione. Tetrahedron Asymmetry 1997, 8 (13), 2075-2077.
  24. Manuel Medarde, Esther Caballero, Fernando Tomé, Concepción P. Melero, Melchor Boya y Arturo San Feliciano. Análogos sintéticos de cardenolidas con estructura simplificada. Derivados perhidroindénicos. Anales de Química 1995, 91, 89-94.
  25. Manuel Medarde, Fernando Tomé, José Luis López, Esther Caballero, Melchor Boya, Concepción P. Melero and Arturo San Feliciano. Stereochemical control of perhydroindenes for the synthesis of cardenolide analogues. Tetrahedron Letters 1994, 35, 8683-8686.
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