Sistema de blogs Diarium
Universidad de Salamanca
Página personal de Concha Pérez Melero
Área de Química Farmacéutica
 
Modelado molecular

Publicaciones

1. Elena González-Hernández, Rubén Aparicio, Mercedes Garayoa, M. José Montero, M. Ángeles Sevilla and Concepción Pérez-Melero.
     Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents
     Med. Chem. Commun. 2019, 10, 1589-1598

2. Concepción Pérez-Melero.
     KSP inhibitors as antimitotic agents
     Current Topics in Medicinal Chemistry 2014, 14, 2286-2311

3. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Pelaez and Manuel Medarde.
     Exploring the effect of 2,3,4-trimethoxyphenyl moiety as a component of indolephenstatins
     European Journal of Medicinal Chemistry 2010, 45, 588-597

4. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Pelaez and Manuel Medarde.
     Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation
     Bioorganic and Medicinal Chemistry 2008, 16, 8999-9008

5. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, José Luis López, Concepción Pérez-Melero, Rafael Pelaez and Manuel Medarde.
     Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization
     Bioorganic and Medicinal Chemistry 2008, 16, 5952-5961

6. Carmen Mateo, Raquel Álvarez, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde.
     Conformationally restricted macrocyclic analogues of combretastatins
     Bioorganic and Medicinal Chemistry Letters 2007, 17, 6316-6320

7. Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde.
     Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins
     Bioorganic and Medicinal Chemistry Letters 2007, 17, 3417-3420

8. Carmen Mateo, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde.
     Synthesis of a conformationally restricted polyoxygenated crownophane
     Tetrahedron Letters 2005, 46 (41), 7055-7057

9. Finian Leeper, Dan Hawksley, Stéphane Mann, Concepción Pérez-Melero and Martin D. H. Wood.
     Studies on thiamine diphosphate-dependent enzymes
     Biochemical Society Transactions 2005, 33, 772-775

10. Carmen Mateo, Concepción Pérez-Melero, Rafael Peláez and Manuel Medarde.
     Stilbenophane analogues of deoxycombretastatin A-4
     Journal of  Organic Chemistry 2005, 70, 6544-6547

11. Ana B. S. Maya, Concepción Pérez-Melero, Carmen Mateo, Dulce Alonso, José Luis Fernández, Consuelo Gajate, Faustino Mollinedo, Rafael Peláez, Esther Caballero   and Manuel Medarde.
     Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety
      Journal of Medicinal Chemistry 2005, 48 (2), 556-568

12. Ana B. S. Maya, Concepción Pérez-Melero, Rafael Peláez, Esther Caballero and Manuel Medarde.
      New naphthylcombretastatins. Modifications on the ethylene bridge
      Bioorganic and Medicinal Chemistry 2005, 13 (6), 2097-2107

13. Concepción Pérez-Melero, Ana B. S. Maya, Benedicto del Rey, Rafael Peláez, Esther Caballero and Manuel Medarde.
      A new family of quinoline and quinoxaline analogues of combretastatins
      Bioorganic and Medicinal Chemistry Letters 2004, 14, 3771-3774

14. Manuel Medarde, Ana B. S. Maya and Concepción Pérez-Melero.
      Naphthalene combretastatin analogues. Synthesis, cytotoxicity and antitubulin activity
      Journal of Enzyme Inhibition and Medicinal Chemistry 2004, 19 (6), 521-540

15. Stéphane Mann, Concepción Pérez-Melero and Finian J. Leeper.
       Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate
      Organic and Biomolecular Chemistry 2004, 2, 1732-1741

16. Luis G. Sevillano, Concepción P. Melero, Esther Caballero, Fernando Tomé, Lionel G. Lelièvre, Kathi Geering, Gilles Crambert, Rosalía Carrón, Manuel Medarde y Arturo San Feliciano.
      Inotropic activity of hydroindenic amidinohydrazones
      Journal of Medicinal Chemistry 2002, 45, 127-136

17. Concepción P. Melero, Manuel Medarde and Arturo San Feliciano.
      A short review on cardiotonic steroids and their aminoguanidine analogues
      Molecules 2000, 5, 51-81

18. Luis G. Sevillano, Concepción P. Melero, Melchor Boya, José Luis López, Fernando Tomé, Esther Caballero, Rosalía Carrón, M. José Montero, Manuel Medarde and Arturo San Feliciano.
      Synthesis and inotropic activity of hydroindene derivatives
      Bioorganic and Medicinal Chemistry 1999, 7, 2991-3001

19. Concepción P. Melero, Luis G. Sevillano, Esther Caballero, Fernando Tomé, Rosalía Carrón, M. José Montero, Arturo San Feliciano and Manuel Medarde.
      Hydroindenic guanylhydrazones. Synthesis and evaluation as inotropic agents
      Bioorganic and Medicinal Chemistry Letters 1998, 8, 3217-3222

20. Manuel Medarde, Esther Caballero, Concepción P. Melero, Fernando Tomé and Arturo San Feliciano.
      Asymmetric synthesis of (+)-3a-Hydroxy-4,7a-dimethylperhydroindane-1,5-dione
      Tetrahedron Asymmetry 1997, 8 (13), 2075-2077

21. Manuel Medarde, Esther Caballero, Fernando Tomé, Concepción P. Melero, Melchor Boya y Arturo San Feliciano.
      Análogos sintéticos de cardenolidas con estructura simplificada. Derivados perhidroindénicos
      Anales de Química 1995, 91, 89-94

22. Manuel Medarde, Fernando Tomé, José Luis López, Esther Caballero, Melchor Boya, Concepción P. Melero and Arturo San Feliciano.
      Stereochemical control of perhydroindenes for the synthesis of cardenolide analogues
      Tetrahedron Letters 1994, 35, 8683-8686

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