Grupo de investigación/Group:

Olfatometría electrónica

http://diarium.usal.es/olfatousal/

OBJETIVO DE LA INVESTIGACIÓN/RESEARCH

La línea de trabajo de éste grupo de investigación está centrada en el desarrollo de metodologías rápidas, sencillas y automatizadas para identificación y cuantificación de analitos en diferentes tipos de muestras. Los problemas abordados están relacionados con el análisis ambiental, agroalimentario, farmacéutico y clínico. Más información sobre el grupo puede encontrarse en el enlace superior.

The aim of the OLFATOUSAL group is the development of automated, fast and simple methodologies for the identification and quantification of different types of analytes in several matrices. Currently, our research is focused on environmental, food and clinical analysis. For more information, please go to the url direction provided.

• Líneas de investigación/Research areas

1. Metodologías no separativas/Non-separative methodologies

Obtención de perfiles de volátiles “huella dactilar” mediante la utilización de narices electrónicas basadas en espectrometría de masas (fuente de ionización, ionización electrónica), así como análisis por inyección en flujo acoplado a espectrometría de masas (fuente de ionización por electrospray).

The development of nonseparative methods for the detection of different analytes based on mass spectrometry detection (electronic noses and flow injection analysis coupled to mass spectrometry). With this approach, it is not necessary to separate the individual compounds of a sample to resolve the analytical problem in hand, it sufficing to obtain a signal profile of the sample formed by all the components integrating it.

2. Metodologías separativas basadas en cromatografía de gases/Separative methodologies based on gas chromatography

2.1. Determinación de contaminantes emergentes y no emergentes en aguas/Determination of emerging and non-emerging contaminants in soils and water samples.

2.2. Control de productos farmacéuticos/Pharmaceutical products analysis.

2.3. Control de fibras textiles/Textile analysis.

2.4. Determinación de analitos en combustibles de automoción/Determination of target compounds in motor fuels.

2.5. Determinación de biomarcadores en líquidos biológicos/Determination of biomarkers in biological fluids.

2.6. Análisis alimentarion/Food analysis.

2.7. Desarrollo de diversas metodologías basadas en líquidos iónicos/Methodology development based on ionic liquids.

• Últimas publicaciones/Latest publications
  

- Fernández del Campo García, María Teresa; Casas Ferreira, Ana María; Rodríguez Gonzalo, Encarnación; Moreno Cordero, Bernardo, Pérez Pavón, José Luis. “Development of a screening and confirmatory method for the analysis of polar endogenous compounds in saliva based on a liquid chromatographic-tandem mass spectrometric system” Journal of Chromatography A (2019) https://doi.org/10.1016/j.chroma.2019.01.001

- Martín Santos, Patricia; del Nogal Sánchez, Miguel; Pérez Pavón, José Luis; Moreno Cordero, Bernardo, Verde Fernández, Rubén. “Liquid-liquid extraction-programmed temperature vaporizer-gas chromatography-mass spectrometry for the determination of polycyclic aromatic hydrocarbons in saliva samples. Application to the occupational exposure of firefighters” Talanta 192 (2019) 69-78.

- Casas Ferreira, Ana María; del Nogal Sánchez, Miguel; Pérez Pavón, José Luis; Moreno Cordero, Bernardo. “Non-separative mass spectrometry methods for non-invasive medical diagnostics based on volatile organic compounds: A review” Analytica Chimica Acta 1045 (2019) 10-22.

- Martín Santos, Patricia; del Nogal Sánchez, Miguel; Pérez Pavón, José Luis; Moreno Cordero, Bernardo. “Quantitative and qualitative analysis of polycyclic aromatic hydrocarbons in urine samples using a non-separative method based on mass spectrometry” Talanta 181 (2018) 373-379.

- González Paredes, Rosa María; García Pinto, Carmelo; Pérez Pavón, José Luis; Moreno Cordero, Bernardo. “Headspace-gas chromatography-mass spectrometry for the rapid determination of possible biomarkers in urine samples” Analytical Methods 9 (2017) 5784-5790.

- Martín Santos, Patricia; del Nogal Sánchez, Miguel; Crisolino Pozas, Ángel Pedro; Pérez Pavón, José Luis; Moreno Cordero, Bernardo. “Determination of ketones and ethyl acetate—a preliminary study for the discrimination of patients with lung cancer”. Analytical and Bioanalytical Chemistry 409 (2017) 5689-5696.

- García Ramos, Álvaro; Pérez Antón, Ana; del Nogal Sánchez, Miguel; Pérez Pavón, José Luis, Moreno Cordero, Bernardo. “Urinary volatile fingerprint based on mass spectrometry for the discrimination of patients with lung cancer and controls” Talanta 174 (2017) 158-164).

- Pérez Pavón, José Luis; del Nogal Sánchez, Miguel; Casas Ferreira, Ana María; Moreno Cordero, Bernardo. “Mass Spectrometry-based Electronic Nose for Bioanalysis” Encyclopedia of Analytical Chemistry (2017) a9592.

- Casas Ferreira, Ana María; Moreno Cordero, Bernardo; Pérez Pavón, José Luis. “Use of microextraction by packed sorbent directly coupled to an electron ionization single quadrupole mass spectrometer as analternative for non-separative determinations” Journal of Chromatography B 1043 (2017) 74-80.

- Pérez Pavón, José Luis; del Nogal Sánchez, Miguel. “Aldehydes and ketones : Headspace gas Chromatography” Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (2016).

- González Paredes, Rosa María; García Pinto, Carmelo; Pérez Pavón, José Luis; Moreno Cordero, Bernardo. “Derivatization coupled to headspace programmed-temperature vaporizer gas chromatography with mass spectrometry for the determination of amino acids: Application to urine samples” Journal of Separation Science 39 (2016) 3375-3383.

- Pérez Antón, Ana; del Nogal Sánchez, Miguel; Crisolino Pozas, Ángel Pedro; Pérez Pavón, José Luis. “Headspace-programmed temperature vaporizer-mass spectrometry and pattern recognition techniques for the analysis of volatiles in saliva samples” Talanta 160 (2016) 21-27.

- Pérez Antón, Ana; García Ramos, Álvaro; del Nogal Sánchez, Miguel; Pérez Pavón, José Luis; Moreno Cordero, Bernardo; Crisolino Pozas, Ángel Pedro. “Headspace-programmed temperature vaporization-mass spectrometry for the rapid determination of possible volatile biomarkers of lung cancer in urine” Analytical and Bioanalytical Chemistry 408 (2016) 5236-5246.

- Casas Ferreira, Ana María; Moreno Cordero, Bernardo; Pérez Pavón, José Luis. “Use of microextraction by packed sorbents and gas chromatography-mass spectrometry for the determination of polyamines and related compounds in urine” Journal of Chromatography A 1444 (2016) 32-41.

- Xu, Jin; Amir Sayed, Blayme; Casas Ferreira, Ana María; Srinivasan, Parthi; Heaton, Nigel; Rela, Mohammed; Ma, Yun; Fuggle, Susan; Legido-Quigley, Cristina; Jassem, Wayel. “The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors” PLOS One (2016).