Farmacocinética clínica.
Desarrollo y validación de modelos farmacocinéticos/farmacodinámicos (PK/PD)de población utilizando datos generados en la práctica clínica. Habitualmente datos generados en la práctica de la monitorización de niveles serios o plasmáticos de los fármacos y sus metabólicos activos. He trabajado con diferentes fármacos pertenecientes a distintos grupos farmacológicos: antineoplásicos, antiepilépticos, inmunosupresores, antirretrovirales, antibióticos…
AREA OF EXPERTISE
The research area in which I have been working focuses on Clinical Pharmacokinetics of different groups of drugs including antiepileptic, antidepressants, inmunosuppressants and certain antibiotics such as vancomycin. The data analysed are generated in Therapeutic Drug Monitoring (TDM), a practice used at our Pharmacy Service in collaboration with different Clinical Services at the UniversityHospital. Since such data are sparse and imbalanced we use Population Pharmacokinetics approach for their management, mainly employing non linear mixed modelling effets implemented in NONMEM program to obtain pharmacokinetic parameters that will reflect the kinetics behaviour of drug disposition in different populations. A further important aim in our research is to find the covariates (demographic, physiopathologic and clinical factors) which could account for some of the inter e intra-varibility in the pharmacokinetic of these drugs.
KEYWORDS: Clinical Pharmacokinetics, Population pharmacokinetics, antiepileptics, tacrolimus, vancomycin, antidepressants
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