Sistema de blogs Diarium
Universidad de Salamanca
Juan Carlos Arévalo
Dpto. Biología Celular y Patología, Instituto de Neurociencias Castilla y León
Hippocampal neuron


  • Martín-Rodríguez, C., Song, M., Anta, B., González-Calvo, F.J., Deogracias, R., Jing, D., Lee, F.S., Arevalo, J.C. TrkB deubiquitination by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation. J. Cell Science. 2020. Dec 7:jcs.247841. doi: 10.1242/jcs.247841.
  • Suelves, N., Miguez, A., López-Benito, S., Garcia Diaz-Barriga, G., Giralt, A., Álvarez, E., Arévalo, J.C., Alberch, J., Gines, S. and Brito, V. Early downregulation of p75NTR by genetic and pharmacological approaches delays the onset of motor deficits and striatal dysfunction in Huntington´s disease mice. Mol. Neurob. 2019, 56:935-953.
  • López-Benito, S., Sánchez-Sánchez, J., Brito, V., Calvo, L., Lisa, S., Torres-Valle, M., Palko, M.E., Vicente-García, C., Fernández-Fernández, S., Bolaños, J.P., Ginés, S., Tessarollo,L. and Arévalo, J.C. Regulation of BDNF release by ARMS/Kidins220 through modulation of Synaptotagmin-IV levels. J. Neurosci. 2018; 38: 5415-5428.
  • Arévalo, J.C., Hernández-Jiménez, E., Jiménez-González, A., Torres-Valle, M., Iwasaki, R.S., López-Bellido, R., Vicente-García, C., Rodríguez, R.E. Generation and characterization of antibodies against opioid receptors from zebrafish. Int. J Mol. Sci. 2018; 19: 14.
  • Sousa-Valente, J., Calvo, L., Vacca, V., Simeoli, R., Arévalo, J.C. and Malcangio, M. Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model. Osteoarthritis Cartilage 2018; 26:88-94.
  • Sánchez-Sánchez, J. & Arévalo, J.C. A review on ubiquitination of neurotrophin receptors: facts and perspectives. Int. J Mol. Sci. 2017; 18: 630.
  • Rosa, M., Gonzalez-Nunez, V., Barreto-Valer, K., Marcelo, F., Sánchez-Sánchez, J., Calle, L.P., Arévalo, J.C., Rodríguez, R.E., Jiménez Barbero, J., Arsequell, G. and Valencia, G. Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides. Bioorganic & Medicinal Chemistry 2017; 25: 2260-2265.
  • Pediaditakis, I., Efstathopoulos, P., Prousis, K.C., Zervou, M., Arévalo, J.C., Alexaki, V.I., Nikoletopoulou, V., Karagianni, E., Potamitis, C., Tavernarakis, N., Chavakis, T., Margioris, A.N., Venihaki, M., Calogeropoulou, T., Charalampopoulos, I., Gravanis, A. Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation. Neuropharmacology 2016; 111:266-2.
  • Anta, B., Martín-Rodríguez, C., Gomis-Pérez, C., Calvo, L., López-Benito, S., Calderón-García, A.A., Vicente-García, C., Villarroel, A. and Arévalo, J.C. Ubiquitin Specific Protease 36 (USP36) controls Neuronal precursor cell-Expressed Developmentally Down-regulated 4-2 (Nedd4-2) actions over the neurotrophin receptor TrkA and potassium voltage-gated channels 7.2/3 (Kv7.2/3). J. Biol. Chem. 2016; 291:19132-45.
  • López-Benito, S., Lillo, C., Hernández-Hernández, A., Chao, M.V. and Arévalo, J.C. ARMS/Kidins220 and Synembryn-B levels regulate NGF-mediated secretion. J. Cell Science. 2016; 129: 1866-77. Cover caption
  • Jimenez-Gonzalez, A., García-Concejo, A., López-Benito, S., Gonzalez-Nunez, V.,  Arévalo, J.C. and Rodriguez, R.E. Role of morphine, miR-212/132 and mu opioid receptor in the regulation of Bdnf in zebrafish embryos. BBA – General Subjects 2016; 1860: 1308-1316.
  • Urresti, J., Ruiz-Meana, M., Coccia, E., Arévalo, J.C., Castellano, J., Fernandez-Sanz, C., Galenkamp, K.M.O., Planells-Ferrer, L., Moubarak, R.S., Llecha-Cano, N., Reix, S., Garcia-Dorado, D., Barneda-Zahonero, B. and Comella, J.X. Lifeguard inhibits Fas ligand-mediated endoplasmic reticulum-calcium release mandatory for apoptosis in type II apoptotic cells. J. Biol. Chem. 2016; 291:1221-34.
  • Paniagua, A.E., Herranz-Martín, S., Jimeno, D., Jimeno, A., López-Benito, S., Arévalo, J.C., Velasco, A., Aijón, J. and Lillo C. CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium. Scientific Reports 2015; 5: 14504.
  • Arévalo, J.C. Nedd4-2 regulation of voltage-gated ion channels: an update on structure-function relationships and the pathophysiological consequences of dysfunction. Journal of Receptor, Ligand and Channel Research 2015; 8: 53-63.
  • Calvo, L., Anta, B., López-Benito, S., Martín-Rodríguez, C., Lee, F.S., Pérez, P., Martín-Zanca, D. and Arévalo, J.C. Bex3 dimerization regulates NGF-dependent neuronal survival and differentiation by enhancing trkA gene transcription. J. Neurosci. 2015; 35: 7190-7202.
  • Lamas, V., Arévalo, J.C., Juiz, J.M., Merchán, M.A. Acoustic input and efferent activity regulate the expression of molecules involved in cochlear micromechanics. Front Syst Neurosci. 2015; 8:253.
  • *Yu, T., *Calvo, L., Anta, B., López-Benito, S., López-Bellido, R., Vicente-Garcia, C., Tessarollo, L., Rodríguez, R.E. and Arévalo, J.C. In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J. Neurosci. 2014; 34: 6098-6106. *Equal contribution
  • Shroff, S., Mierzwa, A., Scherer, S.S., Peles, E., Arevalo, J.C., Chao, M.V., Rosenbluth, J. Paranodal permeability in “myelin mutants”. Glia. 2011; 59: 1447-57.
  • Duffy, A.M., Schaner, M.J., Wu, S.H., Staniszewski, A., Kumar, A., Arévalo, J.C., Arancio, O., Chao, M.V., Scharfman, H.E. A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Experimental Neurology. 2011; 229: 409-20.
  • Yu, T., Calvo, L., Anta, B., López-Benito, S., Southon, E., Chao, M.V., Tessarollo, L., Arévalo, J.C. Regulation of trafficking of activated TrkA is critical for NGF-mediated functions. Traffic. 2011; 12: 521-34.
  • Wu, S.H., Arévalo, J.C., Neubrand, V.E., Zhang, H., Arancio, O., Chao, M.V. The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity. J Biol Chem. 2010; 285: 40472-8.
  • Park, H.J., Park, H.W., Lee, S.J., Arévalo, J.C., Park, Y.S., Lee, S.P. Paik, K.S., Chao, M.V. and Chang, M.S.  Ankyrin Repeat-Rich Membrane Spanning/Kidins220 Protein Interacts with Mammalian Septin 5. Molecules and Cells 2010; 30: 143-8.
  • *Arévalo, J.C., Wu, S.H., Takahashi, T., Zhang, H., Yu, T., Yano, H., Milner, T.A., Tessarollo, L., Ninan, I., Arancio, O. and *Chao, M.V. The ARMS/Kidins220 scaffold protein modulates synaptic transmission. Mol. Cell. Neurosci. 2010; 45: 92-100. * Corresponding authors
  • Mierzwa, A.J., Arevalo, J.C., Schiff, R., Chao, M.V. and Rosenbluth, J. Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant mice. J Comp Neurol. 2010; 518: 2841-53.
  • Wu,S.H., Arévalo, J.C., Sarty, F., Pang, F., Tessarollo, L., Gan, W.B. and Chao, M.V. ARMS/Kidins220 regulates dendritic branching and spines in vivo. Developmental Neurobiology 2009; 69: 547-57.
  • Cortés,R.Y., Arévalo, J.C., Magby, J.P., Chao, M.V. and Plummer, M.R. Developmental and activity-dependent regulation of ARMS/Kidins220 in cultured rat hippocampal neurons. Developmental Neurobiology 2007; 67: 1687-1698.
  • *Arévalo, J.C. & Gu, S.H. Neurotrophin signaling: many exciting surprises!  Cell. Mol. Life Sci. 2006; 63: 1523-1537. *Corresponding author
  • *Arévalo, J.C.; Waite, J.; Rajagopal, R.; Beyna, M.; Chen, Z.Y.; Lee, F.S., and *Chao, MV. Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 2006; 50: 549-559. * Corresponding authors
  • Arévalo, J.C.; Pereira, D.; Yano, H.; Teng, K.K., and Chao, M.V. Identification of a switch in neurotrophin signaling by selective tyrosine-phosphorylation. J. Biol. Chem. 2006; 281:1001-7.
  • *Arévalo, J.C. & *Chao, M.V. Axonal growth: where neurotrophins meet Wnts. Curr. Opin. Cell Biol. 2005; 17: 112-115. * Corresponding authors
  • Pedraza, C.E.; Podlesniy, P.; Vidal, N.; Arévalo, J.C.; Lee, R.; Hempstead, B.; Ferrer, I.; Iglesias, M. and Espinet. C. Pro-NGF isolated from the human brain affected by Alzheimer’s disease induces neuronal apoptosis mediated by p75NTR. Am J Pathol. 2005; 166: 533-43.
  • Luo, S., Chen, Y., Lai, K.-O., Arévalo, J.C., Froehner, S.C., Adams, M.E., Chao, M.V., Ip, N.Y. α-syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner. J. Cell Biol. 2005; 169: 813-824.
  • Chang, M.S.; Arévalo, J.C. and Chao, M.V. A ternary complex with the Trk, p75 and an ankyrin-rich membrane spanning protein. J. Neurosc. Res. 2004; 78: 186-192.
  • Arévalo, J.C.; Yano, H.; Teng, K.K., and Chao, M.V. A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane spanning protein. EMBO J. 2004; 23: 2358-68.
  • Chittka, A.; Arévalo, J.C.; Rodriguez-Guzman, M.; Pérez, P.; Chao, M.V., and Sendtner, M. The p75NTR interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E. J. Cell Biol. 2004; 164: 985-996.
  • Harrington, A.W.; Leiner, B.J.; Blechschmitt, C.; Arévalo, J.C.; Lee, R.; Morl, K.; Meyer, M.; Hempstead, B.L.; Yoon, S.O., and Giehl, K. Secreted proNGF is the in vivo pathophysiological ligand for p75 after CNS axotomy. PNAS 2004; 101: 6226-6230.
  • Yano, H.; Lee, F.; Kong, H.; Chuang, J.Z.; Arévalo, J.C.; Pérez, P.; Sung, C.H., and Chao, M.V. Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. J. Neurosci. 2001; 21: RC125.
  • Arévalo, J.C.; Conde, B.; Hempstead, B.L.; Chao, M.V.; Martín-Zanca, D., and Pérez, P. A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation. Oncogene. 2001; 20: 1229-34.
  • Arévalo, J.C.; Conde, B.; Hempstead, B.L.; Chao, M.V.; Martín-Zanca, D., and Pérez, P. TrkA immunoglobuline-like ligand binding domains inhibit spontaneous activation of the receptor. Mol. Cell. Biol. 2000; 20: 5908-5916.
  • Arévalo, J.C.; Pérez-González, M.N.; Sánchez-Bernal, C., and Llanillo, M. Phosphlipid fatty acid and lipid peroxidation in liver microsomes from guinea pigs fed oil related to the toxic oil syndrome. Comp. Biochem. Phys. C 1998; 120: 111-119.
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